Publications
PrecivityAD® and PrecivityAD2™ Tests - Research & Trials
Impact on Clinical Trial Enrollment, Design and Economics
Angioni D, Hansson O, Bateman RJ, et al. Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials? A Report from the EU/US CTAD Task Force. J Prev Alzheimers Dis. 2023. doi.org/10.14283/jpad.2023.68
Schindler SE, Li Y, Li M, et al. Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment. Alzheimers Dement. 2023;19(4):1175-1183. doi:10.1002/alz.12754
Analyte Performance
Wisch J, Gordon B, Boerwinkle A, et al. Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40. Alzheimers Dement. 2023;15(1):e12405. Published 2023 Mar 2. doi:10.1002/dad2.12405
Hartz SM, Mozersky J, Schindler SE, et al. A flexible modeling approach for biomarker‐based computation of absolute risk of Alzheimer’s disease dementia. Alzheimers Dement. 2023;19(4):1452-1465. doi:10.1002/alz.12781
Winston CN, Langford O, Levin N, et al. Evaluation of blood-based plasma biomarkers as potential markers of amyloid burden in preclinical Alzheimer’s disease. J Alzheimers Dis. 2023; 92(1), 95–107. doi.org/10.3233/JAD-221118
Aschenbrenner AJ, Li Y, Henson RL, et al. Comparison of plasma and CSF biomarkers in predicting cognitive decline. Ann Clin Transl Neurol 2022; 9(11):1739-1751. doi:10.1002/acn3.51670
Meeker KL, Luckett PH, Barthélemy NR, et al. Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease. Brain Commun. 2024;6(2):fcae081. Published 2024 Mar 15. doi:10.1093/braincomms/fcae081
Bayat S, Roe CM, Schindler S, et al. Everyday Driving and Plasma Biomarkers in Alzheimer's Disease: Leveraging Artificial Intelligence to Expand Our Diagnostic Toolkit. J Alzheimers Dis. 2023;92(4):1487-1497. doi:10.3233/JAD-221268
Treatment Monitoring (Research Use)
Sims JR, Zimmer JA, Evans CD, et al. Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ2 Randomized Clinical Trial. JAMA. 2023. Published online July 17, 2023.* doi:10.1001/jama.202313239
Rafii MS, Sperling RA, Donohue MC, et al. The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease. Alzheimers Dement. 2023;19(4):1227-1233.
doi:10.1002/alz.12748
van Dyck CH, Swanson CJ, Aisen P, et al. Lecanemab in Early Alzheimer's Disease. N Engl J Med. 2023;388(1):9-21. doi:10.1056/NEJMoa2212948
McDade E, Cummings JL, Dhadda S, et al. Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study. Alzheimers Res Ther. 2022;14(1):191. Published 2022 Dec 21. doi:10.1186/s13195-022-01124-2
Swanson CJ, Zhang Y, Dhadda S, et al. A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody [published correction appears in Alzheimers Res Ther. 2022 May 21;14(1):70]. Alzheimers Res Ther. 2021;13(1):80. Published 2021 Apr 17. doi:10.1186/s13195-021-00813-8
* Publication includes Precivity-p-tau217 analyte measurements (part of PrecivityAD2 rather than PrecivityAD) used in longitudinal monitoring