Scientific Publications
A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment
Mark Monane, Kim G. Johnson, B. Joy Snider, Raymond S. Turner, Jonathan D. Drake, Demetrius M. Maraganore, James L. Bicksel, Daniel H. Jacobs, Julie L. Ortega, Joni Henderson, Yan Jiang, Shuguang Huang, Justine Coppinger, Ilana Fogelman, Tim West, & Joel B. Braunstein
Annals of Clinical and Translations Neurology, August 8, 2023
Independent study demonstrates amyloid probability score accurately indicates amyloid pathology
Ilana Fogelman, MD, MPH; Tim West, PhD; Joel B. Braunstein, MD, MBA, Philip B. Verghese, PhD, Kristopher M. Kirmess, PhD; Matthew R. Meyer, PhD; John H. Contois, PhD; Eli Shobin, PhD; Kyle L. Ferber, PhD; Jake Gagnon, PhD; Carrie E. Rubel, PhD; Danielle Graham, PhD; Randall J. Bateman, MD; David M. Holtzman, MD; Shuguang Huang PhD; Joanne Yu, MS; Sha Yang, MA; Kevin E. Yarasheski, PhD
Annals of Clinical and Translational Neurology, March 28, 2023
Head-to-head comparison of 10 plasma phospho-tau assays in predromal Alzheimer’s disease
Shorena Janelidze, Divya Bali, Nicholas J. Ashton, Nicolas R Barthélemy, Jeroen Vanbrabant, Erik Stoops, EugeenVanmechelen,Yingxin He, Anna Orduña Dolado, Gallen Triana-Baltzer, Michael J. Pontecorvo, Henrik Zetterberg, Hartmuth Kolb, Manu Vandijck,Kaj Blennow, Randall J. Bateman and Oskar Hansson
Brain, September 10, 2022
Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment
Yan Hu, PhD, Kristopher M. Kirmess, PhD, Matthew R. Meyer, PhD, Gil D. Rabinovici, MD, Constantine Gatsonis, PhD, Barry A. Siegel, MD, Rachel A. Whitmer, PhD, Charles Apgar, MBA, Lucy Hanna, MS, Michio Kanekiyo, MS, June Kaplow, PhD, Akihiko Koyama, PhD, David Verbel, MPH, Mary S. Holubasch, BS, Stephanie S. Knapik, BS, Jason Connor, PhD8, John H. Contois, PhD, Erin N. Jackson, MS, Scott E. Harpstrite, BS, Randall J. Bateman, MD9, David M. Holtzman, MD9, Philip B. Verghese, PhD, Ilana Fogelman, MD, Joel B. Braunstein, MD, Kevin E. Yarasheski, PhD, Tim West, PhD
JAMA Open Network, 5 (2022).
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light
Suzanne E. Schindler, MD, PhD, Thomas K Karikari, PhD, Nicholas J Ashton, PhD, Rachel L Henson, MS, Kevin E Yarasheski, PhD, Tim West, PhD, Mathew R Meyer, PhD, Kristopher M Kirmess, PhD, Yan Li, PhD, Benjamin Saef, MS,Krista L Moulder, PhD, David Bradford, Anne M Fagan, PhD, Brian A Gordon, PhD, Tammie L.S. Benzinger, MD, PhD, Joyce Balls-Berry, PhD, Randall J Bateman, MD, Chengjie Xiong, PhD, Henrik Zetterberg, MD, PhD, Kaj Blennow,MD, PhD, John C Morris, MD
Neurology - First published April 21, 2022
The PrecivityAD™ Test: Accurate and Reliable LC-MS/MS Assays for Quantifying Plasma Amyloid Beta 40 and 42 and Apolipoprotein E Proteotype for the Assessment of Brain Amyloidosis.
Kirmess KM, Meyer MR, Holubasch MS, Knapik SS, Hu Y, Jackson EN, Harpstrite SE, Verghese PB, West T, Fogelman I, Braunstein J, Yarasheski KE, Contois JH.
Clinica Chimica Acta, 519 (2021), pp. 267-275.
A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis.
West T, Kirmess KM, Meyer MR, Holubasch MS, Knapik SS, Hu Y, Contois JH, Jackson EN, Harpstrite SE, Bateman RJ, Holtzman DM, Verghese PB, Fogelman I, Braunstein JB, Yarasheski KE.
Molecular Neurodegeneration (2021) 16(1):30
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis.
Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Li Y, Gordon BA, Holtzman DM, Morris JC, Benzinger TLS, Xiong C, Fagan AM, Bateman RJ (2019).
Neurology 93:e1647–e1659.
Detection of β-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers.
Tosun D, Veitch D, Aisen P, Jack CR Jr, Jagust WJ, Petersen RC, Saykin AJ, Bollinger J, Ovod V, Mawuenyega KG, Bateman RJ, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Weiner MW.
Brain Commun. 2021 Feb 2;3(2):fcab008. doi: 10.1093/braincomms/fcab008. PMID: 33842885; PMCID: PMC8023542.
Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis.
Ovod V, Ramsey KN, Mawuenyega KG, Bollinger JG, Hicks T, Schneider T, Sullivan M, Paumier K, Holtzman DM, Morris JC, Benzinger T, Fagan AM, Patterson BW, Bateman RJ (2017).
Alzheimers Dement. 13:841–9.